abstract：BACKGROUND AND AIMS:To find new diagnostic markers to monitor isoniazid-induced liver injury. METHODS:SD rats were treated with low dosage of isoniazid and the light microscopic findings of livers were collected. The methylation status of cytochrome p450 2E1 promoter was determined. RESULTS:Cell edema and spotty necr...

journal_title：Environmental toxicology and pharmacology

authors： Shen L,Zhang B,Sun S,Feng F

更新日期：2013-07-01 00:00:00

abstract：:The sensitivity of human lymphocytes from different donors to CdCl2 using a complex of methods for determination of cytotoxicity and genotoxicity was studied. As endpoints for cytotoxicity the mitotic index (MI) and apoptosis were evaluated. To indicate genotoxicity chromosome aberrations test (CA) was used. The resul...

journal_title：Environmental toxicology and pharmacology

authors： Gateva S,Jovtchev G,Stergios M

更新日期：2013-07-01 00:00:00

abstract：:Phthalates are chemicals widely used in industry and the consequences for human health caused by exposure to these agents are of significant current interest. Phthalate toxicity targets the reproductive and respiratory systems primarily, but they also may be involved in the processes of carcinogenesis and even in auti...

journal_title：Environmental toxicology and pharmacology

authors： Ventrice P,Ventrice D,Russo E,De Sarro G

更新日期：2013-07-01 00:00:00

abstract：:In this study, the hepatoprotective effect of dieckol on carbon tetrachloride (CCl4) induced hepatic damages in ICR mice liver was investigated. Mice were randomly divided into 4 groups such as saline treated (negative control), CCl4 treated (positive control), CCl4+dieckol (5mg/kg mouse) and CCl4+dieckol (25mg/kg mou...

journal_title：Environmental toxicology and pharmacology

authors： Kang MC,Kang SM,Ahn G,Kim KN,Kang N,Samarakoon KW,Oh MC,Lee JS,Jeon YJ

更新日期：2013-05-01 00:00:00

abstract：:This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant diffe...

journal_title：Environmental toxicology and pharmacology

authors： Feng H,Gao Y,Zhao L,Wei Y,Li Y,Wei W,Wu Y,Sun D

更新日期：2013-05-01 00:00:00

abstract：:Earthworms are an ideal biological model in toxicity assays and environment monitoring studies, especially for the toxicity of pesticides on soil ecosystem. However, There are very little data on the toxicity of triazoles on earthworms despite the fact that such data are critical in assessing their fate and potential ...

journal_title：Environmental toxicology and pharmacology

authors： Gao M,Song W,Zhang J,Guo J

更新日期：2013-05-01 00:00:00

abstract：:Bisphenol-A (BPA) has been classified as an endocrine disruptor which disrupts normal cell function by acting as an estrogen agonist. Environmentally relevant doses of the Bisphenol-A have profound effects on rat endocrine pancreas, an essential organ involved in glucose homeostasis. Bisphenol-A acts on insulin releas...

journal_title：Environmental toxicology and pharmacology

authors： Jayashree S,Indumathi D,Akilavalli N,Sathish S,Selvaraj J,Balasubramanian K

更新日期：2013-03-01 00:00:00

abstract：:The environmental pollutant bisphenol A dimethacylate (BAD) has been used as a dental composite. The effect of BAD on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in OC2 human oral cancer cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. BAD induced [Ca(2+)]...

journal_title：Environmental toxicology and pharmacology

authors： Chien JM,Chou CT,Lu YC,Lu T,Chi CC,Tseng LL,Liu SI,Cheng JS,Kuo CC,Liang WZ,Jan CR

更新日期：2013-03-01 00:00:00

abstract：:The present study was undertaken to scientifically evaluate, validate and compare the cardioprotective effects of lisinopril (Lsp), an angiotensin converting enzyme (ACE) inhibitor and vitamin E (Vit E), an antioxidant in the setting of ischemia and reperfusion (I-R) injury. An open chest left anterior descending coro...

journal_title：Environmental toxicology and pharmacology

authors： Mohanty IR,Arya DS,Dinda A,Gupta SK

更新日期：2013-03-01 00:00:00

abstract：:The acute toxicity of cypermethrin to the amphipod Hyalella curvispina was evaluated by means of a toxicity test under laboratory conditions. Cypermethrin is one of the most widely used insecticides in Argentina. H. curvispina is a widely distributed and commonly abundant component of the invertebrate assemblages in s...

journal_title：Environmental toxicology and pharmacology

authors： Mugni H,Paracampo A,Marrochi N,Bonetto C

更新日期：2013-01-01 00:00:00

abstract：:Peste des petits ruminants virus (PPRV); a negative sense single stranded RNA enveloped virus that causes Peste des petits ruminants (PPR), is dramatically affecting the health status of ruminants all around the world resulting in extensive economical losses in livestock sector. Acacia nilotica (Linn) Delile; a tannin...

journal_title：Environmental toxicology and pharmacology

authors： Raheel R,Ashraf M,Ejaz S,Javeed A,Altaf I

更新日期：2013-01-01 00:00:00

abstract：:Colorectal cancer is one of the leading causes of cancer related deaths in Western countries and is becoming increasingly common in Asia. Rosmarinic acid (RA), one of the major components of polyphenol possesses attractive remedial features. The purpose of this study is to investigate the possible chemopreventive mech...

journal_title：Environmental toxicology and pharmacology

authors： Karthikkumar V,Sivagami G,Vinothkumar R,Rajkumar D,Nalini N

更新日期：2012-11-01 00:00:00

abstract：:Marine microbes have been a storehouse of bioactive metabolites with tremendous potential as drug candidates. Marine microorganism derived secondary metabolites (chemical compounds/peptides) are considered to be a burning area of research since recent past. Many of such compounds have been proven to be anti-bacterial,...

journal_title：Environmental toxicology and pharmacology

authors： Bhatnagar I,Kim SK

更新日期：2012-11-01 00:00:00

abstract：:Changes in some blood parameters after 12-week administration of sodium metavanadate (SMV; 0.125mgV/ml) or/and magnesium sulphate (MS; 0.06mgMg/ml) in drinking water were studied in outbred male Wistar rats (16 rats/each group) to explore the probable mechanism(s) underlying SMV toxicity and check whether Mg at the le...

journal_title：Environmental toxicology and pharmacology

authors： Ścibior A,Adamczyk A,Gołębiowska D,Niedźwiecka I

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:Present study aimed at determining blood selenium concentration (Se-B) in a selected population of children inhabiting industrial regions. METHODS:The studies were conducted on a group of 267 children inhabiting industrial regions in Upper Silesia (Poland). Determination of Se-B was performed using hydride gen...

journal_title：Environmental toxicology and pharmacology

authors： Gać P,Pawlas N,Poręba R,Poręba M,Prokopowicz A,Pawlas K

更新日期：2012-09-01 00:00:00

abstract：:Pimpinella brachycarpa (Kom.) Nakai (PB) is one of the most favored edible greens grown in Asian regions. In our previously study, we found PB extract had antioxidant effects in vitro. In the present study, an EtOAc soluble extract (PBet) was isolated from PB. Then the antioxidant properties at cellular level, phytoch...

journal_title：Environmental toxicology and pharmacology

authors： Lu J,Qian W,Xu L,Huang G,Cong W,Wang Z,Deng X,Wang D,Guan S

更新日期：2012-09-01 00:00:00

abstract：:Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...

journal_title：Environmental toxicology and pharmacology

authors： Li X,Shi Y,Wei Y,Ma X,Li Y,Li R

更新日期：2012-09-01 00:00:00

abstract：:Deltamethrin, is a commonly used pyrethroid pesticide. Vitamin E is a antioxidant that plays an important role in protecting cells against toxicity by inactivating free radicals generated following pesticides exposure. Therefore, it was evaluated whether deltamethrin induced histopathological changes and nuclear abnor...

journal_title：Environmental toxicology and pharmacology

authors： Kan Y,Cengiz EI,Ugurlu P,Yanar M

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS:Twenty-seven Sprague-Dawley rats were divided...

journal_title：Environmental toxicology and pharmacology

authors： Gul H,Uysal B,Cakir E,Yaman H,Macit E,Yildirim AO,Eyi YE,Kaldirim U,Oztas E,Akgul EO,Cayci T,Ozler M,Topal T,Oter S,Korkmaz A,Toygar M,Demirbag S

更新日期：2012-07-01 00:00:00

abstract：:In Pakistan a huge number of workers is routinely exposed to various types of chemical contaminants but there is a dearth of information as to the impact of these agents, due to a lack of a routine surveillance system and proper reporting. Prolonged and sometimes acute occupational exposures to varied organic chemical...

journal_title：Environmental toxicology and pharmacology

authors： Kamal A,Malik RN,Fatima N,Rashid A

更新日期：2012-07-01 00:00:00

abstract：:The goal of this study was to investigate the mechanisms of nanocopper-induced nephrotoxicity by analyzing renal gene expression profiles phenotypically anchored to conventional toxicological outcomes. Male Wistar rats were given nanocopper (50, 100, 200 mg/kg) and microcopper (200 mg/kg) at different doses for 5 days...

journal_title：Environmental toxicology and pharmacology

authors： Liao M,Liu H

更新日期：2012-07-01 00:00:00

abstract：:The toxicity of chlorobenzenes to Tetrahymena growth metabolism was studied by microcalorimetry. The growth constant (k), peak time (T) and generation times (T(G)) were calculated. IC(50) of chlorobenzenes was obtained through the kinetic parameters. The results suggested that the order of toxicity was 1,2,4-trichloro...

journal_title：Environmental toxicology and pharmacology

authors： Zhang T,Li X,Min X,Fang T,Zhang Z,Yang L,Liu P

更新日期：2012-05-01 00:00:00

abstract：:Coutarea hexandra is a species commonly known in Brazil as quina, and its bark is used in folk medicine. In this study, we assess the mutagenic and DNA-damaging effects of ethanol extracts from C. hexandra stem bark (SCH) and leaves (LCH) by employing the Ames test on the TA98 and TA100 strains of Salmonella typhimuri...

journal_title：Environmental toxicology and pharmacology

authors： Nunes LG,Gontijo DC,Souza CJ,Fietto LG,Carvalho AF,Leite JP

更新日期：2012-03-01 00:00:00

abstract：:Glutathione S-transferase isoenzymes (GSTs) play a critical role in detoxification pathways. Here we report the tissue distribution of four antioxidant GSTs gene in common carp, and their expression profiles. We also investigated the GSTs activity in different tissues after exposure to the agricultural chemicals atraz...

journal_title：Environmental toxicology and pharmacology

authors： Xing H,Wang X,Sun G,Gao X,Xu S,Wang X

更新日期：2012-03-01 00:00:00

abstract：:Fucoidan is a complex sulfated polysaccharide, derived from marine brown seaweed. In the present study, we investigated the effects of fucoidan on improving learning and memory impairment in rats induced by infusion of Aβ (1-40), and its possible mechanisms. The results indicated that fucoidan could ameliorate Aβ-indu...

journal_title：Environmental toxicology and pharmacology

authors： Gao Y,Li C,Yin J,Shen J,Wang H,Wu Y,Jin H

更新日期：2012-03-01 00:00:00

abstract：:Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...

journal_title：Environmental toxicology and pharmacology

authors： Yan F,Wang M,Li J,Cheng H,Su J,Wang X,Wu H,Xia L,Li X,Chang HC,Li Q

更新日期：2012-03-01 00:00:00

abstract：:Present study was designed to compare cytoprotective and antigenotoxic activity of the polyphenolic fraction of Pilea microphylla (PM1) with that of its active polyphenolic constituents against γ-radiation in V79 cells. PM1 was standardized with respect to the polyphenols present by RP-HPLC. It was evaluated for its f...

journal_title：Environmental toxicology and pharmacology

authors： Paul P,Bansal P,Nayak PG,Pannakal ST,Priyadarsini KI,Unnikrishnan MK

更新日期：2012-01-01 00:00:00

abstract：:The study investigated the correlation between infarction areas and behavioural deficits in middle cerebral artery occlusion (MCAO) and photothrombosis stroke models. In the MCAO model, a 0.38 mm-diameter silicone-coated thread was introduced through the left external carotid artery and advanced 18 mm via the internal...

journal_title：Environmental toxicology and pharmacology

authors： Choi BI,Park D,Lee SH,Bae DK,Yang G,Yang YH,Kim TK,Choi EK,Lee HJ,Choi KC,Nahm SS,Kim YB

更新日期：2012-01-01 00:00:00

abstract：:The Opuntia ficus indica f. inermis methanolic flowers extract (OMFE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, linoleic acid peroxidation assays and in vivo evaluated for its ability to prevent ethanol-induced gastri...

journal_title：Environmental toxicology and pharmacology

authors： Alimi H,Hfaiedh N,Bouoni Z,Sakly M,Ben Rhouma K

更新日期：2011-11-01 00:00:00

abstract：:As a first-line anti-tuberculosis drug, isoniazid has a serious adverse side effect: hepatotoxicity. Therefore, the assessment and monitoring of hepatotoxicity from isoniazid to prevent liver injury are great concerns. In this experiment, we compared the levels of ALT in plasma and DNA methylation. 30 male SD rats wer...

journal_title：Environmental toxicology and pharmacology

authors： Zhang B,Sun S,Shen L,Zu X,Chen Y,Hao J,Huang X,Feng F

更新日期：2011-11-01 00:00:00

abstract：:This study was to appraise the anti-inflammatory and free radical scavenging activities of ethanol extracts of Ilex ficoidea Hemsl (EIFH) and Ilex centrochinensis S.Y. Hu (EICC). Anti-inflammatory activities were evaluated using xylene-induced ear edema and the cotton pellet granuloma tests. Some antioxidants produced...

journal_title：Environmental toxicology and pharmacology

authors： Li L,Zhang Y,Zhang P,Pi H,Ruan H,Wu J

更新日期：2011-09-01 00:00:00

abstract：:The aim of this study was to evaluate cytogenotoxic effects of bee venom to human lymphocytes and take a look into the mechanisms behind them. Bee venom was tested in concentrations ranging from 0.1μg/ml to 20μg/ml over different lengths of time. Cell viability, type of the cell death, and morphological alterations we...

journal_title：Environmental toxicology and pharmacology

authors： Gajski G,Garaj-Vrhovac V

更新日期：2011-09-01 00:00:00

abstract：:Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...

journal_title：Environmental toxicology and pharmacology

authors： Sarma SN,Kim YJ,Ryu JC

更新日期：2011-09-01 00:00:00

abstract：:Cadmium (Cd) is a toxic heavy metal, and exposure to Cd causes a range of changes within the cell. At high concentrations, Cd causes damage to cells via a range of mechanisms. At low concentrations, Cd can stimulate expression of genes that are part of an adaptive response. In this study, we have used the astrocytoma ...

journal_title：Environmental toxicology and pharmacology

authors： Lawal AO,Ellis EM

更新日期：2011-07-01 00:00:00

abstract：:Antitumor effects of a ginsenoside Rg(3)-fortified red ginseng preparation (Rg(3)-RGP) were investigated in human non-small cell lung carcinoma (H460) cells using in vitro cytotoxicity assay and in vivo nude mouse xenograft model. Immunomodulatory effects of the preparation were also assessed by measuring the facilita...

journal_title：Environmental toxicology and pharmacology

authors： Park D,Bae DK,Jeon JH,Lee J,Oh N,Yang G,Yang YH,Kim TK,Song J,Lee SH,Song BS,Jeon TH,Kang SJ,Joo SS,Kim SU,Kim YB

更新日期：2011-05-01 00:00:00

abstract：:The toxicokinetic characteristics of naringin were investigated in rats that had been orally administered naringin extract, a candidate for oral treatment of cough, prepared from Citrus grandis "Tomentosa", at 50, 250, or 1250 mg/kg/day in a repeated-dose study for 1, 32, 93, or 184 days. Increased values of the mean ...

journal_title：Environmental toxicology and pharmacology

authors： Liu M,Yang C,Zou W,Guan X,Zheng W,Lai L,Fang S,Cai S,Su W

更新日期：2011-05-01 00:00:00

abstract：:The mutagenic and genotoxic effect of 'Rasayanzine', an atrazine herbicide, was carried out in fish Channa punctatus using micronucleus and single cell gel electrophoresis (SCGE) assays. Three sub-lethal concentrations of the test material viz., SL-I (1/5th LC(50)=∼8.48 mgL(-1)), SL-II (1/8th LC(50)=∼5.30 mgL(-1)) and...

journal_title：Environmental toxicology and pharmacology

authors： Nwani CD,Nagpure NS,Kumar R,Kushwaha B,Kumar P,Lakra WS

更新日期：2011-03-01 00:00:00

abstract：:The Brca1 and Brca2 tumor suppressor genes are involved in the maintenance of genomic integrity as they facilitate error free DNA repair. This study was designed to understand the role of Brca1 and Brca2 in betel nut (BN) induced chronic and transgenerational carcinogenesis in mice. Young male and female Swiss Albino ...

journal_title：Environmental toxicology and pharmacology

authors： Choudhury Y,Sharan RN

更新日期：2011-01-01 00:00:00

abstract：:Since hypoxia-inducible factor-1α (HIF-1α) is the key transcription factor that enables cells to survive in hypoxia, we have investigated whether an upregulation of HIF-1α prevents the noise-induced hearing loss in BALB/c hybrid mice, which were intraperitoneally injected with CoCl(2) (a HIF-1α inducer) and exposed to...

journal_title：Environmental toxicology and pharmacology

authors： Chung JW,Shin JE,Han KW,Ahn JH,Kim YJ,Park JW,So HS

更新日期：2011-01-01 00:00:00

abstract：:This study investigated the cytoprotective effect of baicalein (5,6,7-trihydroxyflavone) against oxidative stress-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed that baicalein showed significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) treat...

journal_title：Environmental toxicology and pharmacology

authors： Lee IK,Kang KA,Zhang R,Kim BJ,Kang SS,Hyun JW

更新日期：2011-01-01 00:00:00